SPORTS GENOMICS: SIGNIFICANCE, PERSPECTIVES AND LIMITATIONS OF APPLICATION
Abstract
"Sports genomics" is a field of science that studies the genome and related molecular genetic methods for studying elite athletes. Currently, a number of legal, ethical, scientific and technical problems of sports genomics have not been resolved. Although the correlation of some gene mutations with the level of sports performance and the risk of sports injuries is known, the question of the direct application of the results of genetic analyzes in sports and recreational activities is still controversial. This article analyzes and compares literature sources on selected aspects of sports genomics in the Medline, PubMed, GrossRef, Türkey Academic Archive (Harman) and РИНЦ databases for 2000-2022. At the end, some final provisions on the selection of a contingent for genetic analysis, their implementation and interpretation of the results are given.
References
1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature. 2010. vol. 467, pp. 1061-1073.
Eroğlu O. Genetik Araştırmaların Spordaki Yeri. İn: The International Balkan Conference in Sport Sciences, 2017. https://hdl.handle.net/11552/2115.
Guilherme J.P.L.F., Lucía A. Introduction to genetics of sport and exercise. In Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions; Barh, D., Ahmetov, I., Eds.; Academic Press: Cambridge, MA, USA, 2019; pp. 3-22.
Guilherme J.P.L.F., Tritto A.C.C., North K.N. et al. Genetics and sport performance: current challenges and directions to the future. Revista Brasileira de Educação Física e Esporte, 2014, vol. 28, pp.177-193.
doi:10.1590/S1807-55092014000100177.
Ahmetov I.I., Hall E.C.R., Semenova E.A. et al. Advances in sports genomics. Adv. Clin. Chem., 2022, vol 107.
Jones N., Kiely J., Suraci B. et al. A genetic-based algorithm for personalized resistance training. Biol. Sport, 2016, vol. 33, p.117.
NCBI Resource Coordinators. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res., 2018, vol. 46, D8–D13.
Vlahovich N., Fricker P.A., Brown M. A. et al. Ethics of genetic testing and research in sport: a position statement from the Australian Institute of Sport. British Journal of Sports Medicine, 2017, vol. 51, pp. 5-11.
World Medical Association. World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. JAMA, 2013, vol. 310(20), pp. 2191-2194.
doi:10.1001/jama.2013.281053.
Guth L.M., Roth S.M. Genetic influence on athletic performance. Curr. Opin. Pediatr., 2013 vol. 25(6), pp.653-658.
doi: 10.1097/MOP.0b013e3283659087.
PMID: 24240283; PMCID: PMC3993978.
Yang N, MacArthur D.G, Gulbin J.P. et al. ACTN3 genotype is associated with human elite athletic performance. Am. J. Hum. Genet., 2003, vol. 73, pp.627-631. doi:10.1086/377590.
Ahmetov A.M., Druzhevskaya I.V., Astratenkova D.V. et al. The ACTN3 R577X polymorphism in Russian endurance athletes. British Journal of Sports Medicine, vol. 44, no. 9, pp. 649-652, Jul. 2010,
doi: 10.1136/bjsm.2008.051540.
Eynon N., Hanson E.D., Lucia A. et al. Genes for elite power and sprint performance: ACTN3 leads the way. Sports Med., 2013, vol. 43, pp. 803-817.
doi:10.1007/s40279-013-0059-4.
Ma F., Yang Y., Li X. et al. The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis.
PLoS ONE, 2013, vol. 8:e54685.
doi:10.1371/journal.pone.0054685.
Ulucan K. Spor Genetiği Açısından Türk Sporcuların ACTN3 R577X Polimorfizm Literatür Özeti. Clin. Exp. Health Sci., 2016, vol. 6, p. 44-47.
Ginn S.L., Alexander I.E., Edelstein M.L. et al. Gene therapy clinical trials worldwide to 2012–an update. J. Gene Med., 2013, vol. 15, pp. 65-77.
doi:10.1002/jgm.2698.
World Anti-Doping Agency. The World Anti-Doping Code: the 2015 Prohibited List International Standard. 2015. http:// www.fivb.org/EN/Medical/Document/WADA-Prohibited-List-2015-EN.pdf. (accessed November 2016).
Maffulli, N., Margiotti, K., Longo, U.G. et el. The genetics of sports injuries and athletic performance. Muscles Ligaments Tendons J. 2013, vol. 3, pp. 173-189.
Thiene G. Sudden cardiac death in the young: A genetic destiny? Clin. Med., 2018, vol. 18, pp. 17-23.
Keywords
genetic analysis спортивная геномика
генетические анализы idman genomikası
genetik analizlər
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