MAKROLAKTON BİRLƏŞMƏLƏRİN TƏSİRİ ALTINDA LİPİD MEMBRANLARINDAN SUBSTRATLARIN SEÇİCİ KEÇİRİCİLİYİNİN TƏDQİQİ

G.M. Behbudova

doi:10.28942/ssj.v3i1.295

Vol. 3 No. 1 (2021)

Original articles

STUDY OF THE SELECTIVE PERMEABILITY OF LIPID MEMBRANES FOR SUBSTRATES UNDER THE ACTION OF MACROLACTONE COMPOUNDS

Published: July 12, 2021

DOI: https://doi.org/10.28942/ssj.v3i1.295

Abstract

Under the action of polyene molecules of amfotericin B, mycoheptin and levorin, are formed channels in the lipid membranes and through these channels the selective permeability for various substrates is studied, for example, the selective permeability for ions and organic compounds is determined. Under the action of polyenes, ions of potassium, sodium, calcium and various organic compounds, including carbohydrates - ribose, arabinose, glucose and sucrose, are transferred through the lipid membranes in this sequence.

References

Касумов Х.М. Открытие одиночных полиеновых каналов и изучение их свойств в мембранах. Монография. Elsevier Lambert Academic Publishing. 2020, pp.1-541.

Sanglard D., Coste A., Ferrari S. Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation. FEMS Yeast Res., 2009, 9 (7), pp.1029-1050. DOI: 10.1021/bi800334p.

Samedova A.A., Tagi-zade T.P., Kasu-mov Kh.M. Dependence of ion channel properties formed by polyene antibiotics molecules on the lactone ring structure. Russian Journal of Bioorganic Chemistry, 2018, vol. 44, No. 3, pp. 337–345. https://doi.org/10.1134/S1068162018030135.

Shahmoradi T., Ashrafpour M., Sepehri H. Electrophysiological characteristics of cationic single-channel formed by incorporation of amphotericin b in bilayer lipid membrane. Journal of Babol University of Medical Sciences, 2016, v. 18 (2). p. 26-31.

Robin Delhom, Andrew Nelson, Valerie Laux, Michael Haertlein, Wolfgang Knecht, Giovanna Fragneto, Hanna P. Wacklin-Knecht. The Antifungal Mechanism of Amphotericin B Elucidated in Ergosterol and Cholesterol-Containing Mem branes Using Neutron Reflectometry. J. Nanomaterials, 2020, 10 (12), 2439; https://doi.org/10.3390/nano10122439.

Cohen B.E. The role of signaling via aqueous pore formation in resistance responses to amphotericin B. Antimicrob. Agents Chemother. 2016, v. 60 (9), pp. 5122–5129. doi: 10.1128/AAC.00878-16.

Yuno Lee, Philip A. Pincus, Changbong Hyeon. Effects of Dimethyl Sulfoxide on Surface Water near Phospholipid Bila-yers. Biophysical Journal, 2016, v. 111 (11), pp. 2481-2491. DOI: 10.1016 / j.bpj.2016.10.033.

Efimova S.S., Schagina L.V., Ostroumova O.S. Investigation of channel-forming activity of polyene macrolide antibiotics in planar lipid bilayers in the presence of dipole modifiers. Acta Naturae, 2014, v. 6(4), pp. 67–79.

Anderson T.M., Clay M.C., Cioffi A.G., Diaz K.A., Hisao G.S., Tuttle M.D., Nieuwkoop A.J., Comellas G., Maryum N., Wang S., Uno B.E., Wildeman E.L, Gonen T., Rienstra C.M., Burke M.D. Amphotericin forms an extramembranous and fungicidal sterol sponge. Nat. Chem. Biol., 2014, v. 10(5), pp. 400 – 406. doi: 10.1038/nchembio.1496.

Tzu-SenYang, Keng-Liang Ou, Pei-Wen Peng, Bing-Chun Liou, Wei-Ting Wang, Yuan-Chen Huang, Chung-Min Tsai. Quantifying membrane permeability of amphotericin B ion channels in single living cells. Biochimica et Biophysica Acta (BBA) - Biomembranes, v. 1828, Issue 8, 2013, pp. 1794-1801.

https://doi.org/10.1016/j.bbamem.2013.03.021.

Neumann A., Baginski M., Czub J. How do sterols determine the antifungal activity of amphotericin B? Free energy of binding between the drug and its mem-brane targets. J. Am. Chem. Soc., 2010, v. 132, pp. 18266-18272. doi: 10.1021 / ja1074344.

Srinivasarao Kintali, Gopal Kishor Varshney, Kaustuv Das. Interaction of Amphotericin B with Ergosterol/Cholesterol-Containing POPG Liposomes Studied by Absorption, Fluorescence and Second Harmonic Spectroscopy. Chemistry Select, 2018, v.3, No 38, pp.10559-10565. https://doi.org/10.1002/slct.201801924.

STUDY OF THE SELECTIVE PERMEABILITY OF LIPID MEMBRANES FOR SUBSTRATES UNDER THE ACTION OF MACROLACTONE COMPOUNDS

Abstract

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