e-ISSN: 2617-0396     print ISSN: 2617-0388
EVALUATION OF DIHYDROPYRIMIDINASE-RELATED PROTEIN 2 IN THE HIGH-CLASS SPORTSMEN’S BLOOD AND SALIVA BEFORE COMPETITION
##common.pageHeaderLogo.altText## Scientific News of Academy of Physical Education and Sport

Abstract

The article concerns evaluation of the levels of dihydropyrimidinase-related protein 2 (DRP2) in the platelets and saliva and natural anti-DRP2 autoantibodies in the serum of the high-class sportsmen before competition beginning. The blood and saliva samples taken from the same sportsmen in quiet and relaxed state served as controls. Evaluation of the levels of DRP2 and natural antiDRP2 autoantibodies was carried out by indirect ELISA test on polysterene plates with moderate level of adsorption. The results indicate to noticeable down regulation of natural antiDRP2 autoantibodies in the serum (p < 0.01) and to lack of any changes of DRP2 levels in the platelets and saliva of these sportsmen before competition beginning. Basing on our earlier data, we come to a conclusion that the results reflects the similar changes of DRP2 level in the sportsmen’s brain subcortical structures and indicate to increase of their aggression level prior to competition beginning.

References

Аллахвердиева Т.Н., Мехтиев Х.Ш., Гайсина А.А., Мехтиев А.А. Серотонин-модулируемый антиконсолидационный белок способствует выживанию животных разных видов при воздействии бактериальных и химических токсинов. Журнал эволюцион. Биохимии и физиологии, 2019, т. 55, № 1, с. 23-27.

Гулиева Ш.М., Мехтиев А.А. Участие дигидропиримидиназа-подобного белка 2 в регуляции тревожности у человека. Российский физиол. Журнал им. И.М.Сеченова, 2023, т. 108, №1, c.34-45.

Catty D., Raikundalia Ch. Immune enzyme analysis. In Catty D (ed) Antibodies. Volume II: A Practical Approach. Oxford University Press, IRL Press, Oxford. 1989, pp. 152-238.

Collins Ch.M., Kloek J., Elliott J.M. Parallel changes in serotonin levels in brain and blood following acute administration of MDMA. J PsychopHarm. 2013, 27:109–112.

Elliott J.M., Kent A. Comparison of [125I] iod-lysergic acid diethylamide binding to human frontal cortex and platelet tissue. J Neurochem. 1989, 53:191-196.

Gaisina A.A., Mekhtiev A.A., Nurullayeva A.N., Palatnikov G.M., Shamilov E.N.The impact of background γ-radiation on erythrocyte nuclear pathology, the serotonergic system, and cytochrome P-450 in hens (Gallus gallus domestıcus) from Azerbaijan.Ecotoxicology. 2022, (5):846-851. Doi:10.1007/s10646-022-02540-8.

Goshima Y., Nakamura F., Strittmatter P. & Strittmatter S.M. Collapsin-indu-ced growth cone collapse mediated by an intracellular protein related to UNC-33. Nature. 1995, 376:509-514.

Hasanova L.F. The changes of serotonin-modulating anticonsolidation protein and dihydropyrimidinase-related protein 2 in the amygdala and blood of depressive rats. Azerbaijan Journal of PHysiology. 2022, 37, 2:7-12.

Huseynov Sh.B., Mekhtiev A.A. Studies of the engagement for serotonergic system in regulation of aggressive behavior in two behavioral models on rats.Journal of Life Sciences & Biomedicine, 2022, V. 4 (77), No 1, p. 97-105.

Inagaki N., Chihara K., Arimura N., Ménager C., Kawano M.N. et al. CRMP -2 induces axons in cultured hippocampal neurons. Nature Neuroscience. 2001, 4: 781–782.

Mekhtiev A.A., Allahverdiyeva T.N., Movsumzadeh S.K. DNA integrity-protecting and survival-promoting activity of serotonergic system in sturgeon juveniles and sazans.Fish PHysiology and Biochemistry. 2017, V. 43, № 4, pp. 1153-1160.

Poletayev A.B. Regulatory autoantibodies. In book: Monoclonal Antibodies in Neurobiology. 1995, Novosibirsk, pp. 37-47.

Rohlf F.J. & Sokal R.R. Statistical tables. In: Biometry: the Principles and Practice of Statistics in Biological Research. 1995. 3rd edn, p. 199. WH Freeman&Co, New York.

pdf (Azərbaycanca)
pdf (Azərbaycanca)

Keywords

sportsmen
platelets
serum
dihydropyrimidinase-related protein 2 (DRP2)
natural anti - DRP2 autoantibodies
indirect ELISA test
sport’s competition спортсмены
тромбоциты
сыворотка крови
дигидропипимидиназа-подобный белок 2 (ДПБ2)
естественные аутоантитела к ДПБ2
непрямой иммуноферментный анализ
спортивные соревнования idmançılar
trombositlər
qan zərdabı
dihidropirimidinazaya bənzər zülal 2 (DBZ2)
DBZ2-yə qarşı təbii autoanticisimlər
dolayı immunoenzim analizi
idman yarışları
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.